Article
Evidence for the intimate relationship between vesicle budding from the ER and the unfolded protein response.
Biochemical and biophysical research communications - 23 Aug 2002
Sato Miyuki, Sato Ken, Nakano Akihiko
Abstract excerpt
Yeast Saccharomyces cerevisiae Sec12p, an ER membrane protein, carries out an essential function as the guanine nucleotide exchange factor of the small GTPase Sar1p. Sar1p-GTP is pivotal for the assembly of a coat protein complex, COPII, on the ER membrane, and thus Sec12p can be regarded as the initiator of vesicle budding from the ER. In an effort to identify genes that positively regulate Sec12p, we isolated...
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