Article
A regulatory link between ER-associated protein degradation and the unfolded-protein response.
Nature cell biology - 1 Jul 2000
Friedlander R, Jarosch E, Urban J, Volkwein C, Sommer T
Abstract excerpt
Ubiquitin conjugation during endoplasmic-reticulum-associated degradation (ERAD) depends on the activity of Ubc7. Here we show that Ubc1 acts as a further ubiquitin-conjugating enzyme in this pathway. Absence of both enzymes results in marked stabilization of an ERAD substrate and induction of the unfolded-protein response (UPR). Furthermore, basic ERAD activity is sufficient to eliminate unfolded proteins under...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.