Article
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals.
Current opinion in cell biology - 1 Jun 2001
Patil C, Walter P
Abstract excerpt
Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the transcriptional response, conservation of the system's elements has allowed identification of corresponding and additional components of the mammalian...
Topics
- Animals
- Apoptosis
- Cell Nucleus
- Endoplasmic Reticulum
- Endoribonucleases
- Evolution, Molecular
- Fungal Proteins
- Genetic Variation
- Humans
- Mammals
- Membrane Glycoproteins
- Membrane Proteins
- Protein Biosynthesis
- Protein Folding
- Protein Serine-Threonine Kinases
- Saccharomyces cerevisiae Proteins
- Signal Transduction
- Transcription, Genetic