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Article

IRE1 and efferent signaling from the endoplasmic reticulum

1 Nov 2000

Abstract excerpt

Genetic analysis of the cellular adaptation to malfolded proteins in the endoplasmic reticulum (the unfolded protein response - UPR) has revealed a novel signaling pathway initiated by activation of IRE1, an ER-resident protein kinase and endonuclease. In yeast, Ire1p activates gene expression by promoting a non-conventional splicing event that converts the mRNA encoding the Hac1p transcription factor from an...

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PMID: 11034898
DOI: 10.1242/jcs.113.21.3697

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