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Article

The avidity spectrum of T cell receptor interactions accounts for T cell anergy in a double transgenic model.

The Journal of experimental medicine - 18 Jan 1999

Girgis L, Davis M M, Fazekas de St Groth B

Abstract excerpt

The mechanism of self-tolerance in the CD4(+) T cell compartment was examined in a double transgenic (Tg) model in which T cell receptor (TCR)-alpha/beta Tg mice with specificity for the COOH-terminal peptide of moth cytochrome c in association with I-Ek were crossed with antigen Tg mice. Partial deletion of cytochrome-reactive T cells in the thymus allowed some self-specific CD4(+) T cells to be selected into...

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Identifiers

PMID: 9892609
DOI: 10.1084/jem.189.2.265
PMCID: PMC2192997

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