Article
The avidity spectrum of T cell receptor interactions accounts for T cell anergy in a double transgenic model.
The Journal of experimental medicine - 18 Jan 1999
Girgis L, Davis M M, Fazekas de St Groth B
Abstract excerpt
The mechanism of self-tolerance in the CD4(+) T cell compartment was examined in a double transgenic (Tg) model in which T cell receptor (TCR)-alpha/beta Tg mice with specificity for the COOH-terminal peptide of moth cytochrome c in association with I-Ek were crossed with antigen Tg mice. Partial...
Topics
- Animals
- Antigens, CD
- CD4-Positive T-Lymphocytes
- Clonal Anergy
- Cytochrome c Group
- Flow Cytometry
- Genotype
- Histocompatibility Antigens Class II
- Interleukin-2
- Lymph Nodes
- Mice
- Mice, Transgenic
- Moths
- Muramidase
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Interleukin-2
- Recombinant Fusion Proteins