Article
Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicity.
Cellular immunology - 10 Apr 1997
Gapin L, Cabaniols J P, Cibotti R, Ojcius D M, Kourilsky P, Kanellopoulos J M
Abstract excerpt
The induction of T-cell tolerance to self-antigens has been extensively characterized for immunodominant (ID) regions. However, tolerance toward other minor self-determinants has received less attention. In the H-2(d) haplotype, HEL contains a single ID determinant (region 102-120) presented by I...
Topics
- Animals
- Cell Line
- Histocompatibility Antigens Class II
- Immune Tolerance
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Muramidase
- Mutation
- Peptide Fragments
- T-Lymphocytes