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Article

A nondeletional mechanism of peripheral tolerance in T-cell receptor transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991

Morahan G, Hoffmann M W, Miller J F

Abstract excerpt

To investigate tolerance to extrathymic self molecules, we produced two groups of transgenic mice: one expressed the major histocompatibility complex molecule H-2Kb in pancreatic beta cells, and the other expressed rearranged T-cell receptor genes encoding an anti-H-2Kb receptor. The transgenic T-cell receptor genes were shown to confer the correct specificity and to be expressed appropriately. T cells bearing...

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Identifiers

PMID: 1662395
DOI: 10.1073/pnas.88.24.11421
PMCID: PMC53147

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