Article
A nondeletional mechanism of peripheral tolerance in T-cell receptor transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991
Morahan G, Hoffmann M W, Miller J F
Abstract excerpt
To investigate tolerance to extrathymic self molecules, we produced two groups of transgenic mice: one expressed the major histocompatibility complex molecule H-2Kb in pancreatic beta cells, and the other expressed rearranged T-cell receptor genes encoding an anti-H-2Kb receptor. The transgenic T-cell receptor genes were shown to confer the correct specificity and to be expressed appropriately. T cells bearing...
Topics
- Animals
- Base Sequence
- Chromosome Deletion
- Gene Expression
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Graft Survival
- H-2 Antigens
- Immune Tolerance
- Islets of Langerhans