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Article

Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2012

Srikanth Sonal, Jew Marcus, Kim Kyun-Do, Yee Ma-Khin, Abramson Jeff, Gwack Yousang

Abstract excerpt

Orai1 and stromal interaction molecule (STIM)1 are critical components of Ca(2+) release-activated Ca(2+) (CRAC) channels. Orai1 is a pore subunit of CRAC channels, and STIM1 acts as an endoplasmic reticulum (ER) Ca(2+) sensor that detects store depletion. Upon store depletion after T-cell receptor stimulation, STIM1 translocates and coclusters with Orai1 at sites of close apposition of the plasma membrane (PM)...

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Source

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Identifiers

PMID: 22586105
DOI: 10.1073/pnas.1200667109
PMCID: PMC3365170

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).PMID 22586105Read ↗

Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation.Semantic proximity Read ↗

Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Semantic proximity Read ↗

Orai1 is an essential pore subunit of the CRAC channel.Semantic proximity Read ↗

Orais and STIMs: physiological mechanisms and disease.Semantic proximity Read ↗

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.Semantic proximity Read ↗

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STIM and ORAI proteins: crucial roles in hallmarks of cancerSemantic proximity Read ↗

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.Semantic proximity Read ↗

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.Semantic proximity Read ↗

Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1.Semantic proximity Read ↗

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