Article
Calmodulin interaction with hEAG1 visualized by FRET microscopy.
PloS one - 27 May 2010
Gonçalves J Tiago, Stühmer Walter
Abstract excerpt
BACKGROUND: Ca(2+)-mediated regulation of ion channels provides a link between intracellular signaling pathways and membrane electrical activity. Intracellular Ca(2+) inhibits the voltage-gated potassium channel EAG1 through the direct binding of calmodulin (CaM). Three CaM binding sites (BD-C1: 674-683, BD-C2: 711-721, BD-N: 151-165) have been identified in a peptide screen and were proposed to mediate binding....
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