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Article

Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Aug 2007

Wang Hong-Gang, George Meena S, Kim James, Wang Chaojian, Pitt Geoffrey S

Abstract excerpt

As the Ca2+-sensor for Ca2+-dependent inactivation, calmodulin (CaM) has been proposed, but never definitively demonstrated, to be a constitutive Ca(V)1.2 Ca2+ channel subunit. Here we show that CaM is associated with the Ca(V)1.2 pore-forming alpha1C subunit in brain in a Ca2+-independent manner. Within its CaM binding pocket, alpha1C has been proposed to contain a membrane targeting domain. Because ion channel...

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Identifiers

PMID: 17715345
DOI: 10.1523/JNEUROSCI.1720-07.2007
PMCID: PMC6672201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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