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Article

Calmodulin regulates the trafficking of KCNQ2 potassium channels.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2008

Etxeberria Ainhoa, Aivar Paloma, Rodriguez-Alfaro Jose Angel, Alaimo Alessandro, Villacé Patricia, Gómez-Posada Juan Camilo, Areso Pilar, Villarroel Alvaro

Abstract excerpt

Voltage-dependent potassium KCNQ2 (Kv7.2) channels play a prominent role in the control of neuronal excitability. These channels must associate with calmodulin to function correctly and, indeed, a mutation (R353G) that impairs this association provokes the onset of a form of human neonatal epilepsy known as benign familial neonatal convulsions (BFNC). We show here that perturbation of calmodulin binding leads to...

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Source

Identifiers

PMID: 17993630
DOI: 10.1096/fj.07-9712com

Genes

KCNQ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Calmodulin regulates the trafficking of KCNQ2 potassium channels.PMID 17993630Read ↗

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