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Article

Multiple endoplasmic reticulum-associated pathways degrade mutant yeast carboxypeptidase Y in mammalian cells.

The Journal of biological chemistry - 21 Nov 2003

Mancini Roberta, Aebi Markus, Helenius Ari

Abstract excerpt

The degradation of misfolded and unassembled proteins by the endoplasmic reticulum (ER)-associated degradation (ERAD) has been shown to occur mainly through the ubiquitin-proteasome pathway after transport of the protein to the cytosol. Recent work has revealed a role for N-linked glycans in targeting aberrant glycoproteins to ERAD. To further characterize the molecular basis of substrate recognition and sorting...

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PMID: 12954632
DOI: 10.1074/jbc.M302979200

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Multiple endoplasmic reticulum-associated pathways degrade mutant yeast carboxypeptidase Y in mammalian cells.PMID 12954632Read ↗

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