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Article

Genetic profiling of protein burden and nuclear export overload.

eLife - 4 Nov 2020

Kintaka Reiko, Makanae Koji, Namba Shotaro, Kato Hisaaki, Kito Keiji, Ohnuki Shinsuke, Ohya Yoshikazu, Andrews Brenda J, Boone Charles, Moriya Hisao

Abstract excerpt

Overproduction (op) of proteins triggers cellular defects. One of the consequences of overproduction is the protein burden/cost, which is produced by an overloading of the protein synthesis process. However, the physiology of cells under a protein burden is not well characterized. We performed genetic profiling of protein burden by systematic analysis of genetic interactions between GFP-op, surveying both...

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Identifiers

PMID: 33146608
DOI: 10.7554/eLife.54080
PMCID: PMC7673788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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