The p53 tumor suppressor gene. A preliminary clinical study in breast cancer patients.

doi:10.1007/BF02789475

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Article

The p53 tumor suppressor gene. A preliminary clinical study in breast cancer patients.

Cell biophysics - 1 Jan 2000

Micelli G, Donadeo A, Quaranta M

Abstract excerpt

p53 was originally considered to be a nuclear oncogene, but several convergent lines of research have indicated that the wild-type gene functions as a tumor suppressor gene negatively regulating the cell cycle. Mutations in the p53 gene have been detected in many tumor types and seem to be the mo...

Topics

Breast Neoplasms
Enzyme-Linked Immunosorbent Assay
Female
Genes, Suppressor
Genes, p53
Humans
Middle Aged
Mutation
Prognosis
Tumor Suppressor Protein p53

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