Article
Tumor suppressor p53 mutations and breast cancer: a critical analysis.
Advances in cancer research - 1 Jan 1995
Ozbun M A, Butel J S
Abstract excerpt
Alterations in the tumor suppressor gene p53 are the most commonly identified changes in cancer, including neoplasia of the breast. The activity of p53 is regulated post-translationally. Phosphorylation state, subcellular localization, and interaction with any of a number of cellular proteins are likely to influence the function of p53. The exact effect of p53-mediated growth suppression seems to be cell-type...
Topics
- Base Sequence
- Breast Neoplasms
- Female
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Prognosis
- Protein Conformation
- Transcriptional Activation
- Tumor Suppressor Protein p53