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Article

Mutations in pimE restore lipoarabinomannan synthesis and growth in a Mycobacterium smegmatis lpqW mutant.

Journal of bacteriology - 1 May 2008

Crellin Paul K, Kovacevic Svetozar, Martin Kirstee L, Brammananth Rajini, Morita Yasu S, Billman-Jacobe Helen, McConville Malcolm J, Coppel Ross L

Abstract excerpt

Lipoarabinomannans (LAMs) and phosphatidylinositol mannosides (PIMs) are abundant glycolipids in the cell walls of all corynebacteria and mycobacteria, including the devastating human pathogen Mycobacterium tuberculosis. We have recently shown that M. smegmatis mutants of the lipoprotein-encoding lpqW gene have a profound defect in LAM biosynthesis. When these mutants are cultured in complex medium, spontaneous...

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Identifiers

PMID: 18344361
DOI: 10.1128/JB.00200-08
PMCID: PMC2395014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in pimE restore lipoarabinomannan synthesis and growth in a Mycobacterium smegmatis lpqW mutant.PMID 18344361Read ↗

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Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan reveals two lipomannan pools in corynebacterineae.Semantic proximity Read ↗

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