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Article

Characterization of key enzymes involved in triacylglycerol biosynthesis in mycobacteria.

Scientific reports - 24 Jun 2021

Crotta Asis Agostina, Savoretti Franco, Cabruja Matías, Gramajo Hugo, Gago Gabriela

Abstract excerpt

Phosphatidic acid phosphatase (PAP) catalyzes the dephosphorylation of phosphatidic acid (PA) yielding diacylglycerol (DAG), the lipid precursor for triacylglycerol (TAG) biosynthesis. PAP activity has a key role in the regulation of PA flux towards TAG or glycerophospholipid synthesis. In this work we have characterized two Mycobacterium smegmatis genes encoding for functional PAP proteins. Disruption of both...

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Identifiers

PMID: 34168231
DOI: 10.1038/s41598-021-92721-y
PMCID: PMC8225852

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