Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic background.

Abstract excerpt

Mice deficient in proopiomelanocortin peptides (Pomc(-/-)) generated on a 129 (A(w)/ A(w)) genetic background were back-crossed onto the C57BL/6 (a/a) genetic background. These mice exhibited most of the phenotypic characteristics previously reported on the 129 genetic background (Yaswen et al. 1999. Nat. Med. 5: 1066-1070). Adult mice became obese, their adrenals were atrophied, and they had undetectable plasma...

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