Article
Genetic studies of the mouse mutations mahogany and mahoganoid.
Genetics - 1 Aug 1997
Miller K A, Gunn T M, Carrasquillo M M, Lamoreux M L, Galbraith D B, Barsh G S
Abstract excerpt
The mouse mutations mahogany (mg) and mahoganoid (md) are negative modifiers of the Agouti coat color gene, which encodes a paracrine signaling molecule that induces a swithc in melanin synthesis from eumelanin to pheomelanin. Animals mutant for md or mg synthesize very little or no pheomelanin depending on Agouti gene background. The Agouti protein is normally expressed in the skin and acts as an antagonist of...
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