Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background.

Endocrinology - 1 Mar 2005

Slominski Andrzej, Plonka Przemyslaw M, Pisarchik Alexander, Smart James L, Tolle Virginie, Wortsman Jacobo, Low Malcolm J

Abstract excerpt

The original strain of proopiomelanocortin (POMC)-deficient mice (Pomc-/-) was generated by homologous recombination in 129X1/SvJ (A(w)/A(w))-derived embryonic stem cells using a targeting construct that deleted exon 3, encoding all the known functional POMC-derived peptides including alpha MSH,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-MSH
Share to Adrenal Glands
Share to Electron Spin Resonance Spectroscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Color

Share to Melanins

Share to Pigmentation

Share to Pro-Opiomelanocortin

Source

Open in PubMed Open full text

Identifiers

PMID: 15564334
DOI: 10.1210/en.2004-0733
PMCID: PMC1201461

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15564334-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background.PMID 15564334Read ↗

Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic background.Semantic proximity Read ↗

Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors.Semantic proximity Read ↗

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans.Semantic proximity Read ↗

Implications of proopiomelanocortin (POMC) mutations in humans: the POMC deficiency syndrome.Semantic proximity Read ↗

Human hair melanins: what we have learned and have not learned from mouse coat color pigmentation.Semantic proximity Read ↗

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin.Semantic proximity Read ↗

The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male.Semantic proximity Read ↗

The Melanocortin-1 ReceptorSemantic proximity Read ↗

Genetic modifications of mouse proopiomelanocortin peptide processing.Semantic proximity Read ↗

Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene.Semantic proximity Read ↗

Red hair--a desirable mutation?Semantic proximity Read ↗

Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.