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Article

Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice.

The Journal of clinical investigation - 1 Feb 2006

Smart James L, Tolle Virginie, Low Malcolm J

Abstract excerpt

Null mutations of the proopiomelanocortin gene (Pomc) cause obesity in humans and rodents, but the contributions of central versus pituitary POMC deficiency are not fully established. To elucidate these roles, we introduced a POMC transgene (Tg) that selectively restored peripheral melanocortin and corticosterone secretion in Pomc mice. Rather than improving energy balance, the genetic replacement of pituitary...

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Source

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Identifiers

PMID: 16440060
DOI: 10.1172/JCI25243
PMCID: PMC1350998

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice.PMID 16440060Read ↗

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Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).Semantic proximity Read ↗

Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adipositySemantic proximity Read ↗

Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior.Semantic proximity Read ↗

Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.Semantic proximity Read ↗

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin.Semantic proximity Read ↗

Pro-opiomelanocortin (POMC) Deficiency and Peripheral Melanocortins in ObesitySemantic proximity Read ↗

The melanocortin action is biased toward protection from weight loss in miceSemantic proximity Read ↗

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