Article
Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).
Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 2004
Challis B G, Coll A P, Yeo G S H, Pinnock S B, Dickson S L, Thresher R R, Dixon J, Zahn D, Rochford J J, White A, Oliver R L, Millington G, Aparicio S A, Colledge W H, Russ A P, Carlton M B, O'Rahilly S
Abstract excerpt
Inactivating mutations of the pro-opiomelanocortin (POMC) gene in both mice and humans leads to hyperphagia and obesity. To further examine the mechanisms whereby POMC-deficiency leads to disordered energy homeostasis, we have generated mice lacking all POMC-derived peptides. Consistent with a pr...
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