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Article

Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD.

American journal of physiology. Renal physiology - 1 Nov 2003

Thomson R Brent, Mentone SueAnn, Kim Robert, Earle Karen, Delpire Eric, Somlo Stefan, Aronson Peter S

Abstract excerpt

It has been proposed that autosomal dominant polycystic kidney disease (ADPKD)affected renal epithelial cells undergo a phenotypic transition from a highly differentiated absorptive state to a much less differentiated secretory state during cystogenesis and that this transition is accompanied by loss of epithelial cell polarity and mistargeting of specific membrane proteins. We conducted a detailed evaluation of...

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PMID: 12851251
DOI: 10.1152/ajprenal.00153.2003

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BLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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