Article
Current advances in molecular genetics of autosomal-dominant polycystic kidney disease.
Current opinion in nephrology and hypertension - 1 Jan 2001
Wu G
Abstract excerpt
Autosomal-dominant polycystic kidney disease results from at least two causal genes, PKD1 and PKD2. The identical clinical phenotype in human patients and targeted Pkd1 and Pkd2 mutant mouse models provides evidence that both gene products act in the same pathogenic pathway. The discovery of direct PKD1 and PKD2 interactions implies that both gene products, polycystin-1 and polycystin-2, play a functional role in...
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