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Article

Augmented responses to morphine and cocaine in mice with a 12-lipoxygenase gene disruption.

Psychopharmacology - 1 Nov 2003

Walters Carrie L, Wang Bao-Cheng, Godfrey Misty, Sun Duxin, Funk Colin D, Blendy Julie A

Abstract excerpt

RATIONALE: Recent studies have shown that pharmacological inhibition of the 12-lipoxygenase pathway selectively blocks opioid inhibition of GABAergic synaptic currents. A similar mechanism has been shown for the regulation of glutamate release in the ventral tegmental area (VTA) during acute withdrawal from morphine, although the functional significance of these effects in vivo are not known. OBJECTIVES: We have...

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Source

Identifiers

PMID: 12845410
DOI: 10.1007/s00213-003-1526-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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