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Article

Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain.

Genome biology - 1 Jan 2007

Toscano Christopher D, Prabhu Vinaykumar V, Langenbach Robert, Becker Kevin G, Bosetti Francesca

Abstract excerpt

BACKGROUND: Cyclooxygenase (COX)-1 and COX-2 produce prostanoids from arachidonic acid and are thought to have important yet distinct roles in normal brain function. Deletion of COX-1 or COX-2 results in profound differences both in brain levels of prostaglandin E2 and in activation of the transcription factor nuclear factor-kappaB, suggesting that COX-1 and COX-2 play distinct roles in brain arachidonic acid...

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Identifiers

PMID: 17266762
DOI: 10.1186/gb-2007-8-1-r14
PMCID: PMC1839133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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