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Article

Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.

British journal of pharmacology - 1 Mar 2012

Wu Yue, Lousberg Erin L, Moldenhauer Lachlan M, Hayball John D, Coller Janet K, Rice Kenner C, Watkins Linda R, Somogyi Andrew A, Hutchinson Mark R

Abstract excerpt

BACKGROUND AND PURPOSE: Emerging evidence implicates a role for toll-like receptor 4 (TLR4) in the CNS effects of alcohol. The aim of the current study was to determine whether TLR4-MyD88-dependent signalling is involved in the acute behavioural actions of alcohol and if alcohol can activate TLR4-downstream MAPK and NF-κB pathways. EXPERIMENTAL APPROACH: The TLR4 pathway was evaluated using the TLR4 antagonist...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21955045
DOI: 10.1111/j.1476-5381.2011.01572.x
PMCID: PMC3372718

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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