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Article

Regulation of extinction of cocaine-induced place preference by midkine is related to a differential phosphorylation of peroxiredoxin 6 in dorsal striatum.

Behavioural brain research - 15 Sept 2013

Gramage Esther, Pérez-García Carmen, Vicente-Rodríguez Marta, Bollen Silke, Rojo Loreto, Herradón Gonzalo

Abstract excerpt

The neurotrophic factors Midkine (MK) and Pleiotrophin (PTN) have been suggested to modulate drugs of abuse-induced effects. To test this hypothesis, cocaine (10 and 15mg/kg)-induced conditioned place preference (CPP) was rendered in PTN knockout (PTN-/-), MK knockout (MK-/-) and wild type (WT+/+) mice, and then extinguished after repeated saline injections (distributed in 4 extinction sessions). Cocaine induced...

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Source

Identifiers

PMID: 23891929
DOI: 10.1016/j.bbr.2013.07.026

Genes

PTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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