Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High dosage Rhp51 suppression of the MMS sensitivity of DNA structure checkpoint mutants reveals a relationship between Crb2 and Rhp51.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2003

Smeets Monique F M A, Francesconi Stefania, Baldacci Giuseppe

Abstract excerpt

BACKGROUND: In eukaryotic cells DNA structure checkpoints organize the cellular responses of DNA repair and transient cell cycle arrest and thereby ensure genomic stability. To investigate the exact role of crb2+ in the DNA damage checkpoint response, a genetic screen was carried out in order to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to DNA, Fungal
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Suppressor

Share to Methyl Methanesulfonate

Share to Mutagens

Share to Rad51 Recombinase

Share to Schizosaccharomyces pombe Proteins

Source

Identifiers

PMID: 12839619
DOI: 10.1046/j.1365-2443.2003.00657.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12839619-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High dosage Rhp51 suppression of the MMS sensitivity of DNA structure checkpoint mutants reveals a relationship between Crb2 and Rhp51.PMID 12839619Read ↗

The S/M checkpoint at 37 degrees C and the recovery of viability of the mutant poldeltats3 require the crb2+/rhp9+ gene in fission yeast.Semantic proximity Read ↗

Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.Semantic proximity Read ↗

Repair of damaged and mismatched DNA by the XPC homologues Rhp41 and Rhp42 of fission yeast.Semantic proximity Read ↗

Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.Semantic proximity Read ↗

Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin.Semantic proximity Read ↗

The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.Semantic proximity Read ↗

The budding yeast cohesin gene SCC1/MCD1/RHC21 genetically interacts with PKA, CDK and APC.Semantic proximity Read ↗

Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.Semantic proximity Read ↗

Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability.Semantic proximity Read ↗

Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.Semantic proximity Read ↗

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.