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Article

Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.

Molecular and cellular biology - 1 Dec 2005

Nakamura Toru M, Moser Bettina A, Du Li-Lin, Russell Paul

Abstract excerpt

The cellular responses to double-stranded breaks (DSBs) typically involve the extensive accumulation of checkpoint proteins in chromatin surrounding the damaged DNA. One well-characterized example involves the checkpoint protein Crb2 in the fission yeast Schizosaccharomyces pombe. The accumulation of Crb2 at DSBs requires the C-terminal phosphorylation of histone H2A (known as gamma-H2A) by ATM family kinases in...

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Identifiers

PMID: 16314498
DOI: 10.1128/MCB.25.24.10721-10730.2005
PMCID: PMC1316985

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.PMID 16314498Read ↗

Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.Semantic proximity Read ↗

Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.Semantic proximity Read ↗

Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.Semantic proximity Read ↗

Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.Semantic proximity Read ↗

BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.Semantic proximity Read ↗

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.Semantic proximity Read ↗

The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.Semantic proximity Read ↗

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.Semantic proximity Read ↗

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.Semantic proximity Read ↗

Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.Semantic proximity Read ↗

Regulation of checkpoint kinases through dynamic interaction with Crb2.Semantic proximity Read ↗

Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.Semantic proximity Read ↗

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