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Article

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.

Genes & development - 15 Jun 2006

Du Li-Lin, Nakamura Toru M, Russell Paul

Abstract excerpt

Cellular responses to DNA damage involve the relocalization of checkpoint proteins to DNA double-strand breaks (DSBs). The fission yeast checkpoint mediator protein Crb2, a homolog of mammalian 53BP1, forms ionizing radiation-induced nuclear foci (IRIF). The IRIF formation by Crb2 requires histone H2A C-terminal phosphorylation and H4-K20 methylation. However, the relevance of Crb2 relocalization is uncertain,...

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Share to Deoxyribonucleases, Type II Site-Specific
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16778077
DOI: 10.1101/gad.1422606
PMCID: PMC1482479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.PMID 16778077Read ↗

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