Article
Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability.
Oncogene - 11 Nov 2004
Killian Audrey, Le Meur Nathalie, Sesboüé Richard, Bourguignon Jeannette, Bougeard Gaëlle, Gautherot Julien, Bastard Christian, Frébourg Thierry, Flaman Jean-Michel
Abstract excerpt
Since chromosomal instability (CIN) is a hallmark of most cancer cells, it is essential to identify genes whose alteration results into this genetic instability. Using a yeast CIN indicator strain, we show that inactivation of the YMR131c/RRB1 gene, which is involved in early ribosome assembly and whose expression is induced when the spindle checkpoint is activated, alters chromosome segregation and blocks...
Topics
- Amino Acid Sequence
- Anaphase
- Cell Line, Tumor
- Chromosomal Instability
- Chromosome Segregation
- DNA-Binding Proteins
- Gene Expression Regulation, Fungal
- Genes, Essential
- Humans
- Metaphase