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Article

Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability.

Oncogene - 11 Nov 2004

Killian Audrey, Le Meur Nathalie, Sesboüé Richard, Bourguignon Jeannette, Bougeard Gaëlle, Gautherot Julien, Bastard Christian, Frébourg Thierry, Flaman Jean-Michel

Abstract excerpt

Since chromosomal instability (CIN) is a hallmark of most cancer cells, it is essential to identify genes whose alteration results into this genetic instability. Using a yeast CIN indicator strain, we show that inactivation of the YMR131c/RRB1 gene, which is involved in early ribosome assembly and whose expression is induced when the spindle checkpoint is activated, alters chromosome segregation and blocks...

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Source

Identifiers

PMID: 15467761
DOI: 10.1038/sj.onc.1207845

Genes

ORC6
RPL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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