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Article

Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.

Molecular and cellular biology - 1 Oct 2010

Sanders Steven L, Arida Ahmad R, Phan Funita P

Abstract excerpt

Activation of DNA damage checkpoints requires the rapid accumulation of numerous factors to sites of genomic lesions, and deciphering the mechanisms of this targeting is central to our understanding of DNA damage response. Histone modification has recently emerged as a critical element for the correct localization of damage response proteins, and one key player in this context is the fission yeast checkpoint...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20679488
DOI: 10.1128/MCB.00404-10
PMCID: PMC2950520

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.PMID 20679488Read ↗

BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.Semantic proximity Read ↗

Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.Semantic proximity Read ↗

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.Semantic proximity Read ↗

Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.Semantic proximity Read ↗

Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.Semantic proximity Read ↗

Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.Semantic proximity Read ↗

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.Semantic proximity Read ↗

The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.Semantic proximity Read ↗

MDC1 is a mediator of the mammalian DNA damage checkpoint.Semantic proximity Read ↗

Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2.Semantic proximity Read ↗

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.Semantic proximity Read ↗

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