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Article

<i>SLC5A8</i> , a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers

26 Jun 2003

Abstract excerpt

We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has been implicated as a component of an epigenetic mechanism that silences genes in human cancers. Using restriction landmark genome scanning, we performed a global search to identify genes that would be aberrantly...

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Share to Epigenetics and DNA Methylation
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PMID: 12829793
DOI: 10.1073/pnas.1430846100

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