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Article

The homeobox gene MEIS1 is methylated in BRAF (p.V600E) mutated colon tumors.

PloS one - 1 Jan 2013

Dihal Ashwin A, Boot Arnoud, van Roon Eddy H, Schrumpf Melanie, Fariña-Sarasqueta Arantza, Fiocco Marta, Zeestraten Eliane C M, Kuppen Peter J K, Morreau Hans, van Wezel Tom, Boer Judith M

Abstract excerpt

Development of colorectal cancer (CRC) can occur both via gene mutations in tumor suppressor genes and oncogenes, as well as via epigenetic changes, including DNA methylation. Site-specific methylation in CRC regulates expression of tumor-associated genes. Right-sided colon tumors more frequently have BRAF (p.V600E) mutations and have higher methylation grades when compared to left-sided malignancies. The aim of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24244575
DOI: 10.1371/journal.pone.0079898
PMCID: PMC3820613

Genes

MEIS1
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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