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Article

Biological functions of SLC5A8, a candidate tumour suppressor

1 Feb 2005

Abstract excerpt

SLC5A8 is a candidate tumour suppressor gene that is silenced in colon cancer, gastric cancer and possibly other cancers in humans. This gene codes for a transporter belonging to the Na(+)/glucose co-transporter gene family (SLC5). The cancer-associated silencing of the gene involves hypermethylation of CpG islands present in exon 1 of the gene. SLC5A8 is expressed in colon, ileum, kidney and thyroid gland. The...

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PMID: 15667316
DOI: 10.1042/bst0330237

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