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Article

Lack of Aberrant Methylation in an Adjacent Area of Left-Sided Colorectal Cancer.

Yonsei medical journal - 1 Jul 2017

Sambuudash Otgontuya, Kim Hyun Soo, Cho Mee Yon

Abstract excerpt

PURPOSE: The molecular nature and the rate-limiting step of epigenetic field defects in the evolution of left-sided colorectal cancer (LCA) remain uncertain. MATERIALS AND METHODS: The methylation status of 27 candidate field defect markers, six classic CpG island methylator phenotype (CIMP) markers, and LINE-1 were determined in LCA and adjacent normal mucosas (ADJs) from 33 LCA patients and in left normal...

Topics

Age Factors
Biomarkers, Tumor
Case-Control Studies
Colorectal Neoplasms
CpG Islands
DNA Methylation
Female
Humans
Male
Middle Aged
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Promoter Regions, Genetic

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 28540987
DOI: 10.3349/ymj.2017.58.4.749
PMCID: PMC5447105

Genes

KRAS
ALX4
BNIP3
BRAF
DOK5
GDNF
IGFBP3
MAL
MGMT
MYOD1
SFRP1
SPOCK2
WIF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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