Article
Mutation in the Sip1 transcription factor leads to a disturbance of the preconditioning of AMPA receptors by episodes of hypoxia in neurons of the cerebral cortex due to changes in their activity and subunit composition. The protective effects of interleukin-10.
Archives of biochemistry and biophysics - 15 Sept 2018
Turovskaya Maria V, Zinchenko Valery P, Babaev Alexei A, Epifanova Ekaterina A, Tarabykin Victor S, Turovsky Egor A
Abstract excerpt
The Sip1 mutation plays the main role in pathogenesis of the Mowat-Wilson syndrome, which is characterized by the pronounced epileptic symptoms. Cortical neurons of homozygous mice with Sip1 mutation are resistant to AMPA receptor activators. Disturbances of the excitatory signaling components are also observed on such a phenomenon of neuroplasticity as hypoxic preconditioning. In this work, the mechanisms of...
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