Article
Transgenic activation of Ras in neurons promotes hypertrophy and protects from lesion-induced degeneration.
The Journal of cell biology - 25 Dec 2000
Heumann R, Goemans C, Bartsch D, Lingenhöhl K, Waldmeier P C, Hengerer B, Allegrini P R, Schellander K, Wagner E F, Arendt T, Kamdem R H, Obst-Pernberg K, Narz F, Wahle P, Berns H
Abstract excerpt
Ras is a universal eukaryotic intracellular protein integrating extracellular signals from multiple receptor types. To investigate its role in the adult central nervous system, constitutively activated V12-Ha-Ras was expressed selectively in neurons of transgenic mice via a synapsin promoter. Ras-transgene protein expression increased postnatally, reaching a four- to fivefold elevation at day 40 and persisting at...
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