Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis.

Journal of cell science - 1 Dec 2006

Nodé-Langlois Roxanne, Muller Dominique, Boda Bernadett

Abstract excerpt

The biological mechanisms underlying the mental retardation associated with mutation of the ARHGEF6 gene, a Rac1/Cdc42 exchange factor, are still unknown, although defects in the plasticity of synaptic networks have been postulated. We have cloned the rat ARHGEF6 gene and investigated, using a transfection approach, its involvement in spine morphogenesis and its relationship to p21-activated kinase 3 (PAK3). We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendritic Spines
Share to Guanine Nucleotide Exchange Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippocampus

Share to NIH 3T3 Cells

Share to p21-Activated Kinases

Share to Rho Guanine Nucleotide Exchange Factors

Share to RNA, Small Interfering

Share to Tissue Culture Techniques

Source

Identifiers

PMID: 17105769
DOI: 10.1242/jcs.03273

Genes

PAK3
ARHGEF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis.PMID 17105769Read ↗

The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.Semantic proximity Read ↗

Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmissionSemantic proximity Read ↗

ARHGEF6-dependent cytoskeletal regulation underlies a conserved program of forebrain interneuron developmentSemantic proximity Read ↗

The p21-activated kinases in neural cytoskeletal remodeling and related neurological disordersSemantic proximity Read ↗

Coordination of synaptic adhesion with dendritic spine remodeling by AF-6 and kalirin-7.Semantic proximity Read ↗

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.Semantic proximity Read ↗

PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.Semantic proximity Read ↗

The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase.Semantic proximity Read ↗

HACE1 deficiency leads to structural and functional neurodevelopmental defectsSemantic proximity Read ↗

Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.Semantic proximity Read ↗

The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.Semantic proximity Read ↗

Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.