Article
Ras and Rap control AMPA receptor trafficking during synaptic plasticity.
Cell - 23 Aug 2002
Zhu J Julius, Qin Yi, Zhao Mingming, Van Aelst Linda, Malinow Roberto
Abstract excerpt
Recent studies show that AMPA receptor (-R) trafficking is important in synaptic plasticity. However, the signaling controlling this trafficking is poorly understood. Small GTPases have diverse neuronal functions and their perturbation is responsible for several mental disorders. Here, we examine the small GTPases Ras and Rap in the postsynaptic signaling underlying synaptic plasticity. We show that Ras relays...
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