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Article

Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function.

The Journal of biological chemistry - 29 Aug 2003

Fong Chee Wai, Leong Hwei Fen, Wong Esther Sook Miin, Lim Jormay, Yusoff Permeen, Guy Graeme R

Abstract excerpt

Mammalian Sprouty (Spry) proteins are now established as receptor tyrosine kinase-induced modulators of the Ras/mitogen-activated protein kinase pathway. Specifically, hSpry2 inhibits the fibroblast growth factor receptor (FGFR)-induced mitogen-activated protein kinase pathway but conversely prolongs activity of the same pathway following epidermal growth factor (EGF) stimulation, where activated EGF receptors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12815057
DOI: 10.1074/jbc.M301317200

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function.PMID 12815057Read ↗

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