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Article

Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction.

Cellular signalling - 1 Nov 2007

Martínez Natalia, García-Domínguez Carlota A, Domingo Beatriz, Oliva José Luis, Zarich Natasha, Sánchez Agustín, Gutiérrez-Eisman Silvia, Llopis Juan, Rojas José M

Abstract excerpt

Sprouty2 has been widely implicated in the negative regulation of the fibroblast growth factor receptor-extracellular regulated kinase (ERK) pathway. Sprouty2 directly interacts with the adapter protein Grb2, member of the receptor tyrosine kinase-induced signaling pathways. In considering the functional role of Grb2, we investigated whether the interaction with this protein was responsible for ERK pathway...

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Identifiers

PMID: 17689925
DOI: 10.1016/j.cellsig.2007.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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