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Article

Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.

EMBO reports - 1 Jul 2005

Haglund Kaisa, Schmidt Mirko H H, Wong Esther Sook Miin, Guy Graeme R, Dikic Ivan

Abstract excerpt

The ubiquitin ligase Cbl mediates ubiquitination of activated receptor tyrosine kinases (RTKs) and interacts with endocytic scaffold complexes, including CIN85/endophilins, to facilitate RTK endocytosis and degradation. Several mechanisms regulate the functions of Cbl to ensure the fine-tuning of...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 15962011
DOI: 10.1038/sj.embor.7400453
PMCID: PMC1369112

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15962011-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.PMID 15962011Read ↗

The Cbl RING finger C-terminal flank controls epidermal growth factor receptor fate downstream of receptor ubiquitination.Semantic proximity Read ↗

Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function.Semantic proximity Read ↗

E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.Semantic proximity Read ↗

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies.Semantic proximity Read ↗

Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits.Semantic proximity Read ↗

The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.Semantic proximity Read ↗

A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation.Semantic proximity Read ↗

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.Semantic proximity Read ↗

[Ubiquitination-mediated degradation of epidermal growth factor receptor].Semantic proximity Read ↗

Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.Semantic proximity Read ↗

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.Semantic proximity Read ↗

The role of CBL family ubiquitin ligases in cancer progression and therapeutic strategiesSemantic proximity Read ↗

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