Article
EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene.
Oncogene - 8 May 1997
Thien C B, Langdon W Y
Abstract excerpt
The 120 kD product of the c-cbl oncogene is rapidly tyrosine phosphorylated and recruited to the EGF receptor following ligand binding. Cbl's oncogenic potential is activated by a large carboxy-terminal truncation that generated v-cbl and removes the Ring finger and proline-rich SH3-binding domai...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Binding Sites
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Transformation, Neoplastic
- Conserved Sequence
- Epidermal Growth Factor
- ErbB Receptors
- Helminth Proteins
- Mice
- Mutation
- Oncogene Protein v-cbl
- Phosphorylation
- Proline
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-cbl