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Article

Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptors

25 Feb 2003

Abstract excerpt

Cellular Src and epidermal growth factor receptor (EGFR) collaborate in the progression of certain human malignancies, and their cooverexpression characterizes relatively aggressive animal tumors. Our study addressed the mode of oncogenic cooperation and reports that overexpression of c-Src in model cellular systems results in the accumulation of EGFR at the cell surface. The underlying mechanism involves...

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Share to HER2/EGFR in Cancer Research
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PMID: 12604776
DOI: 10.1073/pnas.0437945100

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