Article
The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase.
Science (New York, N.Y.) - 18 Apr 1997
Ota Y, Samelson L E
Abstract excerpt
Engagement of antigen and immunoglobulin receptors on hematopoietic cells is directly coupled to activation of nonreceptor protein tyrosine kinases (PTKs) that then phosphorylate critical intracellular substrates. In mast cells stimulated through the FcvarepsilonRI receptor, activation of several...
Topics
- Animals
- Cell Degranulation
- Enzyme Precursors
- Genetic Vectors
- Intracellular Signaling Peptides and Proteins
- Mast Cells
- Mutation
- Phosphorylation
- Phosphotyrosine
- Protein-Tyrosine Kinases
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-cbl
- Rats
- Receptors, IgE
- Receptors, IgG
- Recombinant Proteins
- Serotonin