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Article

The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase.

Science (New York, N.Y.) - 18 Apr 1997

Ota Y, Samelson L E

Abstract excerpt

Engagement of antigen and immunoglobulin receptors on hematopoietic cells is directly coupled to activation of nonreceptor protein tyrosine kinases (PTKs) that then phosphorylate critical intracellular substrates. In mast cells stimulated through the FcvarepsilonRI receptor, activation of several PTKs including Syk leads to degranulation and release of such mediators of the allergic response as histamine and...

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Source

Identifiers

PMID: 9103201
DOI: 10.1126/science.276.5311.418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase.PMID 9103201Read ↗

The cbl oncogene: a novel substrate of protein tyrosine kinases.Semantic proximity Read ↗

Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells.Semantic proximity Read ↗

Role of CBL Mutations in Cancer and Non-Malignant PhenotypeSemantic proximity Read ↗

Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b.Semantic proximity Read ↗

The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase.Semantic proximity Read ↗

CBL mutations promote activation of PI3K/AKT signaling via LYN kinaseSemantic proximity Read ↗

E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.Semantic proximity Read ↗

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disordersSemantic proximity Read ↗

Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptorsSemantic proximity Read ↗

Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity.Semantic proximity Read ↗

A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes.Semantic proximity Read ↗

The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.Semantic proximity Read ↗

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