Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

doi:10.1038/ncb867

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Article

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

Nature cell biology - 1 Nov 2002

Hanafusa Hiroshi, Torii Satoru, Yasunaga Takayuki, Nishida Eisuke

Abstract excerpt

Sprouty (Spry) inhibits signalling by receptor tyrosine kinases; however, the molecular mechanism underlying this function has not been defined. Here we show that after stimulation by growth factors Spry1 and Spry2 translocate to the plasma membrane and become phosphorylated on a conserved tyrosine. Next, they bind to the adaptor protein Grb2 and inhibit the recruitment of the Grb2-Sos complex either to the...

Topics

Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Animals
Binding, Competitive
COS Cells
Cattle
Cell Line
Cell Membrane
DNA, Complementary
Dimerization
Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Dominant

HeLa Cells

Humans

Immunoblotting

Intracellular Signaling Peptides and Proteins

Luciferases

MAP Kinase Signaling System

Source

Open in PubMed

Identifiers

PMID: 12402043
DOI: 10.1038/ncb867

Genes

FRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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