Article
Polo-like kinase 1 (PLK1) O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma.
The Journal of biological chemistry - 1 Feb 2023
Yan Sheng, Peng Bin, Kan Shifeng, Shao Guangcan, Xiahou Zhikai, Tang Xiangyan, Chen Yong-Xiang, Dong Meng-Qiu, Liu Xiao, Xu Xingzhi, Li Jing
Abstract excerpt
The O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) mediates intracellular O-GlcNAcylation modification. O-GlcNAcylation occurs on Ser/Thr residues and is important for numerous physiological processes. OGT is essential for dividing mammalian cells and is involved in many human diseases; however, many of its fundamental substrates during cell division remain unknown. Here, we focus on the effect of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.