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CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response

2 Oct 2023

Abstract excerpt

Human cancers share requirements for phosphorylation-dependent signaling, mitotic hyperactivity, and survival after DNA damage. The oncoprotein CIP2A (cancerous inhibitor of PP2A) can coordinate all these cancer cell characteristics. In addition to controlling cancer cell phosphoproteomes via inhibition of protein phosphatase PP2A, CIP2A directly interacts with the DNA damage protein TopBP1 (topoisomerase...

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PMID: 37793965
DOI: 10.1016/j.trecan.2023.09.001

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